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Chronic GI stress whether from IBD, IBS, leaky gut, post-antibiotic dysbiosis, or long-term dietary damage creates a self-reinforcing inflammation loop

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doi: 10.1136/ard.2010.140145

In patients with diabetes mellitus, the incidence of GI symptoms is significantly higher than in those without diabetes, especially in women with poor glycemic control, long-standing diabetes, or other diabetic complications, although the reported prevalence of DGE varies widely by region (Krishnasamy and Abell, 2018), with dysphagia (63%), gastroesophageal reflux (41%), early satiety or nausea (10%20%), constipation (60%), and diarrhea (20%) being especially prominent (Revicki et al., 2003